CD20 Rabbit Polyclonal Antibody

This gene encodes a member of the membrane-spanning 4A gene family. Members of this nascent protein family are characterized by common structural features and similar intron/exon splice boundaries and display unique expression patterns among hematopoietic cells and nonlymphoid tissues. This gene encodes a B-lymphocyte surface molecule which plays a role in the development and differentiation of B-cells into plasma cells. This family member is localized to 11q12, among a cluster of family members. Alternative splicing of this gene results in two transcript variants which encode the same protein. [provided by RefSeq, Jul 2008], caution:Epitope 1, mapped in PubMed:16785532, is predicted to be buried in the membrane. Its accessibility to the extracellular space, and thus to antibody recognition, is not explained., function:This protein may be involved in the regulation of B-cell activation and proliferation., online information:CD20 entry, pharmaceutical:Monoclonal antibodies (mAb) against CD20 are used to treat B-cell non-Hodgkin's lymphoma (NHL) . These antibodies include Rituximab (Mabthera), Britumomab (Zevalin) and Tositumomab (Bexxar) . CD20 engaged by mAb can generate transmembrane signals capable of directly controlling cell growth and triggering cell death in certain tumors. Alternatively, mAb can mediate complement-dependent cytotoxicity., PTM:Phosphorylated. Might be functionally regulated by protein kinase (s) ., similarity:Belongs to the MS4A family., tissue specificity:Expressed on B-cells.

MS4A1; CD20; B-lymphocyte antigen CD20; B-lymphocyte surface antigen B1; Bp35; Leukocyte surface antigen Leu-16; Membrane-spanning 4-domains subfamily A member 1; CD antigen CD20