ANKT Rabbit Polyclonal Antibody

NUSAP1 is a nucleolar-spindle-associated protein that plays a role in spindle microtubule organization (Raemaekers et al., 2003 [PubMed 12963707]) .[supplied by OMIM, Jun 2009], domain:The KEN box is required for the FZR1-dependent degradation of this protein subsequent to ubiquitination., function:Microtubule-associated protein with the capacity to bundle and stabilize microtubules (By similarity) . May associate with chromosomes and promote the organization of mitotic spindle microtubules around them., PTM:Phosphorylated upon DNA damage, probably by ATM or ATR., PTM:Ubiquitinated. Ubiquitination by FZR1 may lead to proteasome-dependent degradation of this protein., similarity:Belongs to the NUSAP family., subcellular location:Found in the cytoplasm and nucleolus during interphase and redistributes to the mitotic spindle in prometaphase (By similarity) . Localizes to the mitotic spindle during anaphase and telophase then disappears from around the chromosomes during cytokinesis (By similarity) . Localizes to multiple distinct regions of chromosomes throughout mitosis., subunit:Interacts with DNA and microtubules. Microtubule bundling is inhibited by IPO7, KPNA2 and KPNB1 while association with DNA is also inhibited by IPO7 and KPNA2.