Benzomalvin C
Benzomalvin C is a weak antagonist of the neurokinin-1 (NK1) receptor inhibiting binding of substance P by 46% when used at 100 μg/mL in vitro. It is also a weak inhibitor of indolamine 2,3-dioxygenase (IDO) with an IC50 value of 130 μM for recombinant IDO. It is isolated from Penicillium and contains an epoxide group at C-19 and C-20, which is not present in benzomalvins A, B, or E.
Product Specifications
CAS Number
157047-98-8
UNSPSC
12352005
Hazard Statement
H301-H410
Target
Neurokinin Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
COVID-19-immunoregulation
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/benzomalvin-c.html
Smiles
O=C1C2=C(N=C3N1C4=C(C(N([C@]35O[C@@H]5C6=CC=CC=C6)C)=O)C=CC=C4)C=CC=C2
Molecular Formula
C24H17N3O3
Molecular Weight
395.41
Precautions
P264-P270-P273-P330-P391-P405-P501
References & Citations
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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