Vinculin Rabbit Monoclonal Antibody
Product Specifications
Background
Vinculin is a cytoskeletal protein that plays an important role in the regulation of focal adhesions and embryonic development. Three structural vinculin domains include an amino-terminal head, a short, flexible proline-rich region and a carboxy-terminal tail. In the inactive state, the head and tail domains of vinculin interact to form a closed confirmation. The open and active form of vinculin translocates to focal adhesions where it is thought to be involved in anchoring F-actin to the membrane and regulation of cell migration.
Product Name Alternative
VCL; Vinculin; Metavinculin
Gene Name
VCL
Gene ID
7414
Swiss Prot
P18206
Host
Rabbit
Reactivity
Human, Mouse, Rat
Clonality
Monoclonal
Conjugation
Unconjugated
Applications
WB
Field of Research
Signal Transduction
Purification
Affinity Purification
Dilution
WB 1:500-1:1000
Form
Liquid
Buffer
Liquid in 50mM Tris-Glycine (pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA.
Modification
Unmodified
Molecular Weight
Calculated MW:124 kDa; Observed MW: 124 kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C for 12 months. Avoid freeze/thaw cycles.
Isotype
IgG
Available Sizes
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