Recombinant Human GUCY2C (C-6His)

GUCY2C (Guanylyl Cyclase C), also known as heat-stable enterotoxin receptor, is a type/xa0I transmembrane protein of the guanylate cyclase (gc) family. GUCY2C cell surface expression is confined to luminal surfaces of the intestinal epithelium and a subset of hypothalamic neurons. The inaccessibility of GUCY2C in the apical membranes of polarized epithelial tissue, due to subcellular restriction of GUCY2C, creates a therapeutic opportunity to target metastatic lesions of colorectal origin which have lost apicalbasolateral polarization without concomitant intestinal toxicity. And that CAR-T cells targeting murine GUCY2C were effective against colorectal cancer metastatic to lung in the absence of intestinal toxicities. Human GUCY2C-targeted CAR that could potentially be employed in patients with GUCY2C-expressing gastrointestinal malignancies.

Always centrifuge tubes before opening.Do not mix by vortex or pipetting.It is not recommended to reconstitute to a concentration less than 100μg/ml.Dissolve the lyophilized protein in distilled water.Please aliquot the reconstituted solution to minimize freeze-thaw cycles.

Store at -70°C/-20°C, stable for 6 months after receipt.Store at ≤-70°C, stable for 3 months under sterile conditions after opening. Please minimize freeze-thaw cycles.

Recombinant Human Guanylyl Cyclase C is produced by our Mammalian expression system and the target gene encoding Ser24-Gln430 is expressed with a 6His tag at the C-terminus.