What is the catalog number for Recombinant Human CD177 (C-6His)?

The catalog number for Recombinant Human CD177 (C-6His) is PHH0304.

What sizes are available for Recombinant Human CD177 (C-6His)?

Recombinant Human CD177 (C-6His) is available in the following size(s): 10 µg, 50 µg, 500 µg.

How many pack sizes does Recombinant Human CD177 (C-6His) come in?

Recombinant Human CD177 (C-6His) is available in 3 different pack sizes.

Is Recombinant Human CD177 (C-6His) in stock?

Recombinant Human CD177 (C-6His) is currently made to order / not held in immediate stock. Contact us for lead time.

Recombinant Human CD177 (C-6His)

Product Specifications

Background

CD177 is polymorphic and has at least two alleles: PRV1 and NB1. Human PRV1 is a Glycosyl-Phosphatidylinositol (GPI) -linked cell surface glycoprotein that belongs to the uPAR/CD59/Ly6 family of receptors. PRV1 is expressed by neutrophils and neutrophil precursors, and changes in expression serve as diagnostic markers for myeloproliferative disorders such as polycythemia vera and essential thrombocythemia. PRV1 may also be expressed by Erythroblasts, B cells, and Monocytes. NB1, a Glycosyl-Phosphatidylinositol (GPI) -linked cell surface glycoprotein, was first described in a case of neonatal alloimmune neutropenia. It is reported that CD177 functions as a novel heterophilic binding partner that engages PECAM-1 in membrane-proximal IgD6.

Product Name Alternative

CD177 Antigen; Human Neutrophil Alloantigen 2a; HNA-2a; NB1 Glycoprotein; NB1 GP; Polycythemia Rubra Vera Protein 1; PRV-1; CD177; NB1; PRV1

Accession Number

AAH29167.1

Host

Human Cells

Endotoxin

<1 EU/µg as determined by LAL test.

Purity

Greater than 95% as determined by reducing SDS-PAGE

Form

Lyophilized

Reconstitution

Always centrifuge tubes before opening.Do not mix by vortex or pipetting.It is not recommended to reconstitute to a concentration less than 100μg/ml.Dissolve the lyophilized protein in distilled water.Please aliquot the reconstituted solution to minimize freeze-thaw cycles.

Molecular Weight

42.33 KDa

Shipping Conditions

The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature listed below.

Storage Conditions

Store at -70°C/-20°C, stable for 6 months after receipt.Store at ≤-70°C, stable for 3 months under sterile conditions after opening. Please minimize freeze-thaw cycles.

Formulation

Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.2.

Construct

Recombinant Human Polycythemia Rubra Vera Protein 1 is produced by our Mammalian expression system and the target gene encoding Leu22-Gly407 is expressed with a 6His tag at the C-terminus.