LpxC-IN-5

LpxC-IN-5 is a potent non-hydroxamate LpxC (UDP-3-O-acyl-N-acetylglucosamine deacetylase) inhibitor with an IC50 of 20 nM. LpxC-IN-5 shows antibacterial activity against E. coli ATCC25922, P. aeruginosa ATCC27853, K. pneumoniae ATCC13883 and P. aeruginosa 5567 with MIC of 16, 4, 64, and 4 μg/mL, respectively[1].

Product Specifications

CAS Number

[2253951-38-9]

UNSPSC

12352005

Target

Bacterial

Type

Reference compound

Related Pathways

Anti-infection

Applications

COVID-19-immunoregulation

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/lpxc-in-5.html

Solubility

10 mM in DMSO

Smiles

C[C@@H](C1=NC=CN1CC2=NOC(C#CC3=CC=C(C=C3)OCC(CO)(CO)N)=C2)O

Molecular Formula

C21H24N4O5

Molecular Weight

412.44

References & Citations

[1]Yamada Y, et al. Fragment-Based Discovery of Novel Non-Hydroxamate LpxC Inhibitors with Antibacterial Activity [published online ahead of print, 2020 Nov 19]. J Med Chem. 2020;10.1021/acs.jmedchem.0c01215.