FineTest®594 Anti-Human VEGFR2/CD309 Antibody

KDR, also named as VEGFR-2, FLK1 and CD309, is a receptor for VEGF or VEGFC. KDR which belongs to the protein kinase superfamily, has a tyrosine-protein kinase activity. The VEGF-kinase ligand/receptor signaling system plays a key role in vascular development and regulation of vascular permeability. In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions. KDR functions as the main mediator of VEGF-induced endothelial proliferation, survival, migration, tubular morphogenesis and sprouting. Mutations of this gene are implicated in infantile capillary hemangiomas.

Vascular endothelial growth factor receptor 2 (VEGFR-2) |Fetal liver kinase 1 (FLK-1) |Kinase insert domain receptor (KDR) |Protein-tyrosine kinase receptor flk-1|KDR|FLK1|VEGFR2

Volume per test: 5μL. Each lot of this antibody is quality control tested by flow cytometric analysis. The amount of the reagent is suggested to be used 5 µL of antibody per test (million cells in 100 µL staining volume or per 100 µL of whole blood) . Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use.

FineTest®594 is optimally excited by the green-yellow laser (561–594 nm) and detected using an optical filter centered near 615 nm (e.g., a 615/20 nm bandpass filter) .