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R8-T198wt

Cell-permeable peptide inhibitor of Pim-1 kinase, derived from p27Kip1. Inhibits Pim-1 phosphorylation of p27Kip1 and Bad; induces cell cycle arrest (at G1) and apoptosis in DU145 prostate cancer cells. Also inhibits Pim-1-dependent growth of DU145 cells in vitro and in vivo. Displays no effect on the growth of normal prostate epithelial RPWE-1 cells at concentrations of 10 and 20 μM.

Product Specifications

CAS Number

2305815-72-7

Stability

≥ 2 years

Purity

>98% (HPLC)

Weight

2820.33

Molecular Formula

C111H211N59O26S

Notes

Research use only, not for human use.

Receptor

——

Available Sizes

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