ZIP
Novel, cell-permeable inhibitor of protein kinase Mζ (PKMζ), a constitutively active, atypical PKC isozyme involved in LTP maintenance. Selectively blocks PKMζ-induced synaptic potentiation in hippocampal slices in vitro. Reverses late-phase LTP (IC50 = 1 - 2.5 μM) and produces persistent loss of 1-day-old spatial memory following central administration in vivo.
Product Specifications
CAS Number
863987-12-6
Stability
≥ 2 years
Purity
>98% (HPLC)
Weight
1928.4
Molecular Formula
C90H154N30O17
Notes
Research use only, not for human use.
Receptor
——
Available Sizes
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