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Amivantamab

Amivantamab (JNJ-61186372) is a humanized antibody that recognizes epidermal growth factor receptor (EGFR) and MET proto-oncogene (MET), with anticancer and anti-tumor activities, preventing ligand binding to EGFR and MET and receptor dimerization that inhibits downstream signal transduction. Amivantamab can induce Fc-dependent endocytosis of macrophages and antibody-dependent cytotoxicity of natural killer cells, and can be used to study metastatic non-small cell lung cancer.

Product Specifications

CAS Number

2171511-58-1

Stability

≥ 2 years

Purity

>98% (HPLC)

Weight

145.88 kDa.

Molecular Formula

——

Notes

Research use only, not for human use.

Receptor

C-Met/HGFR | EGFR

Available Sizes

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