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Erastin2

Erastin2 is a ferroptosis inducer and inhibitor of the system xc- cystine/glutamate transporter. It inhibits glutamate release in CCF-STTG1 cells (IC50 = 0.0035 &#181M) and induces cell death in HAP1 cells at 5 &#181M, an effect blocked by ferrostatin-1 or deferoxamine. Erastin2 also induces ferroptotic cell death in HT-1080 cells (EC50 = 0.15 &#181M), an effect blocked by β-mercaptoethanol (EC50 > 20 &#181M) . Additionally, it increases lipid peroxidation in HT-1080 cells at 1 &#181M.

Product Specifications

CAS Number

1695533-44-8

Stability

≥ 2 years

Purity

>98% (HPLC)

Weight

623.14

Molecular Formula

C36H35ClN4O4

Notes

Research use only, not for human use.

Receptor

Ferroptosis

Available Sizes

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