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BMS986260

BMS-986260 is a selective, and orally bioavailable TGFβR1 inhibitor (IC50 = 1.6 nM) . BMS-986260 demonstrated functional activity in multiple TGFβ-dependent cellular assays, excellent kinome selectivity, favorable pharmacokinetic properties, and curative in vivo efficacy in combination with anti-PD-1 antibody in murine colorectal cancer (CRC) models.

Product Specifications

CAS Number

2001559-19-7

Stability

≥ 2 years

Purity

>98% (HPLC)

Weight

382.07

Molecular Formula

C18H12ClFN6O

Notes

Research use only, not for human use.

Receptor

TGFβR1

Available Sizes

Curated Selection

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