PG106

PG106 is a potent and selective human melanocortin 3 (hMC3) receptor antagonist (IC50=210 nM) and has noactivity at hMC4 receptors (EC50=9900 nM) and hMC5 receptor[1].

Product Specifications

CAS Number

[944111-22-2]

UNSPSC

12352209

Target

Melanocortin Receptor

Type

Peptides

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/pg106.html

Solubility

10 mM in DMSO

Smiles

[Ac-{Nle}-D-{Bal}-{D-Nal}-RWK-NH2(Lactambridge:Asp2-Lys7)]

Molecular Formula

C51H69N13O9

Molecular Weight

1008.18

References & Citations

[1]Paolo Grieco, et al. Further structure-activity studies of lactam derivatives of MT-II and SHU-9119: their activity and selectivity at human melanocortin receptors 3, 4, and 5. Peptides