IL17B, Human

GoldBio growth factors are manufactured for RESEARCH USE ONLY and cannot be sold for human consumption!Recombinant Human Interleukin-17BIL17BNeuronal interleukin-17-related factor, NIRFIL17B, also named IL20, NIRF and ZCYTO7, belongs to the IL17 family and it stimulates the release of tumor necrosis factor alpha (TNF-α) and IL1-beta from the monocytic cell line THP-1. IL17B mRNA is expressed in adult pancreas, small intestine, and stomach. The IL17 family is comprised of at least six proinflammatory cytokines that share a conserved cysteine-knot structure but diverge at the N-terminus. IL17 family members are glycoproteins secreted as dimers that induce local cytokine production and recruit granulocytes to sites of inflammation. IL17B binds the IL17B receptor, but not the IL17 receptor; it is most homologous with IL17D, which is expressed by resting CD4+ T cells and CD19+ B cells. Immunohistochemical analysis of several nerve tissues indicates that this cytokine is primarily localized to neuronal cell bodies.Sterile Filtered White lyophilized powder. Purified and tested for use in cell culture.Source:Escherichia coliMW: ~36.4 kDa (2x 161 amino acids) Purity: >95% by SDS-PAGE and HPLC analyses.Biological Activity:Fully biologically active when compared to standard. The ED50as determined by inducing IL-8 secretion of human HepG2 cells is less than 1.0 μg/ml, corresponding to a specific activity of >1000 IU/mg.