Camptothecin (Camptotheca acuminata)

Camptothecin is an alkaloid compound used as an anti-cancer agent. It is a topoisomerase I inhibitor in DNA synthesis. Camptothecin has been shown to bind and stabilize a topoisomerase I-DNA complexin vitro, preventing the enzyme from reannealing DNA strands. This inhibition specifically effects the S-phase of cell development and ultimately results in apoptosis due to damaged DNA.Camptothecin is produced by endosymbiotic fungi, from the divisionAscomycota (Phycomycete), that are present in the treeCamptotheca acuminatawhich is native to southern China.Camptothecin (Mappia foetida), (GoldBio Catalog # C-565) has also been isolated from fungi onMappia foetida (Nothapodytes foetida), a plant common to India.Product SpecificationsCamptothecin (Camptotheca acuminata) Formula: C20H16N2O4MW: 348.65 g/mol