Kynurenic acid-d5

Kynurenic acid-d5 is the deuterium labeled Kynurenic acid. Kynurenic acid, an endogenous tryptophan metabolite, is a broad-spectrum antagonist targeting NMDA, glutamate, α7 nicotinic acetylcholine receptor. Kynurenic acid is also an agonist of GPR35/CXCR8[1][2].

Product Specifications

CAS Number

[350820-13-2]

Product Name Alternative

Quinurenic acid-d5

UNSPSC

12352005

Hazard Statement

H315, H319, H335

Target

Apoptosis; CXCR; Endogenous Metabolite; GPR35 ; iGluR; Isotope-Labeled Compounds

Type

Isotope-Labeled Compounds

Related Pathways

Apoptosis; GPCR/G Protein; Immunology/Inflammation; Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease; Neuronal Signaling; Others

Field of Research

Inflammation/Immunology; Neurological Disease; Endocrinology

Purity

99.64

Solubility

0.1 M NaOH : 12.5mg/mL (ultrasonic; adjust pH to 9 with NaOH) |10 mM in DMSO

Smiles

OC1=C([2H])C(C(O)=O)=NC2=C1C([2H])=C([2H])C([2H])=C2[2H]

Molecular Formula

C10H2D5NO3

Molecular Weight

194.20

Precautions

H315, H319, H335

References & Citations

[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216. |[2]Wang J, et al. Kynurenic acid as a ligand for orphan G protein-coupled receptor GPR35. J Biol Chem. 2006 Aug 4;281 (31) :22021-8.|[3]Albuquerque EX, et al. Kynurenic acid as an antagonist of α7 nicotinic acetylcholine receptors in the brain: facts and challenges. Biochem Pharmacol. 2013 Apr 15;85 (8) :1027-32.|[4]Małaczewska J, et al. Effect of oral administration of kynurenic acid on the activity of the peripheral blood leukocytes in mice. Cent Eur J Immunol. 2014;39 (1) :6-13.