MIG (CXCL9)
MIG, a CXC chemokine, is produced by IFN stimulated monocytes, macrophages and endothelial cells. It signals through the CXCR3 receptor. MIG selectively chemoattracts Th1 lymphocytes, and also exerts other activities including inhibition of tumor growth, angiogenesis, and inhibition of colony formation of hematopoietic progenitors. Human MIG is active on murine cells. Recombinant human MIG is an 11.7 kDa protein containing 103 amino acid residues, including the four highly conserved cysteine residues present in CXC chemokines.
Product Specifications
Synonyms
CMK; MIG; Humig; SCYB9; crg-10
NCBI Gene ID
4283
UniProt
Q07325
Accession Number
NP_002407.1
Accession Number mRNA
NM_002416.1
Chromosomal Location
4q21
Reactivity
Human
Cross Reactivity
Human, Mouse
Sequence
TPVVRKGRCS CISTNQGTIH LQSLKDLKQF APSPSCEKIE IIATLKNGVQ TCLNPDSADV KELIKKWEKQ VSQKKKQKNG KKHQKKKVLK VRKSQRSRQK KTT
Endotoxin
< 0.1 ng/µg of protein (< 1EU/µg)
Purity
> 98% by SDS-PAGE & HPLC analyses
Bioactivity
Determined by its ability to chemoattract human peripheral blood T lymphocytes using a concentration range of 10.0-100.0 ng/ml.
Length
103
Form
Lyophilized
Molecular Weight
11.7 kDa
Host or Source
E. coli
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