MFH290
MFH290 is a selective covalent inhibitor targeting CDK12/13 via Cys-1039. It suppresses Pol II CTD Ser2 phosphorylation and DNA damage repair gene expression, synergizing with PARP inhibitors like olaparib in preclinical cancer models. This mechanism supports its research use in oncology, particularly for studying transcription-targeted therapies and synthetic lethality.
Product Specifications
CAS Number
2088715-91-5
Field of Research
Cell Biology
Smiles
C (=O) (N1C[C@H] (NC=2SC (SCC=3OC (C (C) (C) C) =CN3) =CN2) CCC1) C4=CC=C (NC (C=C) =O) C=C4
Molecular Formula
C26H31N5O3S2
Molecular Weight
525.69
Storage Conditions
-20°C
Notes
For research use only.
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