EGFR (phospho Tyr1110) Antibody
Product Specifications
Background
Receptor for EGF, but also for other members of the EGF family, as TGF-alpha, amphiregulin, betacellulin, heparin-binding EGF-like growth factor, GP30 and vaccinia virus growth factor. Is involved in the control of cell growth and differentiation. Phosphorylates MUC1 in breast cancer cells and increases the interaction of MUC1 with SRC and CTNNB1/beta-catenin.
NCBI Gene ID
1956
Swiss Prot
P00533
Accession Number
NP_005219.2
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
EGFR (phospho-Tyr1110) antibody was raised against a peptide sequence around phosphorylation site of tyrosine 1110 (P-V-Y (p) -H-N) derived from Human EGFR.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Phospho-Specific
Purification
Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.
Concentration
1 mg/mL
Buffer
Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Modification
Phospho-Specific
Shipping Conditions
Blue Ice
Storage Conditions
Store antibody at -20˚ C for up to one year.
Calculated Molecular Weight
175 kDa
Specificity
This antibody detects endogenous level of EGFR only when phosphorylated at tyrosine 1110.
Applications Notes
Western Blot: 1:500~1:1000
Symbol
EGFR
NCBI Official Name
Epidermal growth factor receptor
NCBI Organism
Homo sapiens
Background Reference 01
Kaisa Erjala, et, al. (2006) Clin. Cancer Res Jul 2006; 12: 4103 - 4111. Judit Anido, et, al. (2003) Clin. Cancer Res ; 9: 1274. Julian Andreev, et, al. (2001) J. Biol. Chem ; 276: 20130 - 20135. Suil Kim, et, al. (2002) Am J Physiol Lung Cell Mol Physiol, ; 283: 67.
Other Product Names
ERBB, HER1, mENA, ERBB1, PIG61, A4, AD1, Receptor protein-tyrosine kinase ErbB-1, kinase EGFR
Tested Applications
WB
Protein ID
29725609
Physical Properties
Liquid
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