HDAC4 (phospho Ser632) Antibody

Product Specifications

Background

Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4) . Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Involved in muscle maturation via its interaction with the myocyte enhancer factors such as MEF2A, MEF2C and MEF2D.

NCBI Gene ID

9759

Swiss Prot

P56524

Accession Number

NP_006028.2

Host

Rabbit

Reactivity

Human, Mouse, Rat

Immunogen

HDAC4 (Phospho-Ser632) antibody was raised against a peptide sequence around phosphorylation site of serine 632 (A-Q-S (p) -S-P) derived from Human HDAC4.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Phospho-Specific, Cell Cycle

Purification

Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.

Concentration

1 mg/mL

Buffer

Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Modification

Phospho-Specific

Shipping Conditions

Blue Ice

Storage Conditions

Store antibody at -20˚ C for up to one year.

Calculated Molecular Weight

140 kDa

Specificity

This antibody detects endogenous level of HDAC4 only when phosphorylated at serine 632.

Applications Notes

Western Blot: 1:500~1:1000

Symbol

HDAC4

NCBI Official Name

Histone deacetylase 4

NCBI Organism

Homo sapiens

Background Reference 01

Wang AH, et al. (2000) Mol Cell Biol. 20 (18) : 6904-6912. Grozinger CM, et al. (2000) Proc Natl Acad Sci U S A. 97 (14) : 7835-7840.

Other Product Names

HD4, AHO3, BDMR, HDACA, HA6116, HDAC-4, HDAC-A, AML1, CBFA2, HD4

Tested Applications

Protein ID

153085395

Physical Properties

Liquid

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