AWL-II-38.3
Product Specifications
UNSPSC Description
AWL-II-38.3 is a potent ephrin-A receptor (EphA3) kinase inhibitor. AWL-II-38.3 does not exhibit significant cellular activity against Src-family kinases nor against b-raf[1][2][1][2].
Target Antigen
Others
Type
Reference compound
Related Pathways
Others
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/awl-ii-38-3.html
Purity
99.71
Solubility
DMSO : 66.67 mg/mL (ultrasonic)
Smiles
O=C(C1=CC=NO1)NC2=CC(NC(C3=CC(C(F)(F)F)=CC(N4C=NC(C)=C4)=C3)=O)=CC=C2C
Molecular Weight
469.42
References & Citations
[1] Yongmun Choi, et al. Discovery and structural analysis of Eph receptor tyrosine kinase inhibitors. Bioorg Med Chem Lett. 2009 Aug 1;19(15):4467-70.|[2]Efrat Mashiach-Farkash, et al. Computer-based identification of a novel LIMK1/2 inhibitor that synergizes with salirasib to destabilize the actin cytoskeleton. Oncotarget. 2012 Jun;3(6):629-39.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-18832/AWL-II-38-3-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-18832/AWL-II-38-3-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
1135205-94-5
Available Sizes
Curated Selection
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