AWL-II-38.3

AWL-II-38.3 is a potent ephrin-A receptor (EphA3) kinase inhibitor. AWL-II-38.3 does not exhibit significant cellular activity against Src-family kinases nor against b-raf[1][2][1][2].

Product Specifications

CAS Number

[1135205-94-5]

UNSPSC

12352005

Target

Ephrin Receptor

Type

Reference compound

Related Pathways

Protein Tyrosine Kinase/RTK

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/awl-ii-38-3.html

Purity

99.71

Solubility

DMSO : ≥ 100 mg/mL

Smiles

O=C(C1=CC=NO1)NC2=CC(NC(C3=CC(C(F)(F)F)=CC(N4C=NC(C)=C4)=C3)=O)=CC=C2C

Molecular Formula

C23H18F3N5O3

Molecular Weight

469.42

References & Citations

[1] Yongmun Choi, et al. Discovery and structural analysis of Eph receptor tyrosine kinase inhibitors. Bioorg Med Chem Lett. 2009 Aug 1;19 (15) :4467-70.|[2]Efrat Mashiach-Farkash, et al. Computer-based identification of a novel LIMK1/2 inhibitor that synergizes with salirasib to destabilize the actin cytoskeleton. Oncotarget. 2012 Jun;3 (6) :629-39.