CD2 Antibody [RPA-2.10]
Product Specifications
Background
The RPA-2.10 monoclonal antibody specifically binds to human CD2, a 50 kDA type I transmembrane glycoprotein. CD2 is expressed on NK cells, thymocytes, T lymphocytes, and B cell subsets. CD2 is involved in cell-cell adhesion, T cell activation, and T cell signaling. Its ligand is CD58 and it is reported to bind to CD48, CD59, and CD15. The RPA-2.10 antibody is reported to be cross-reactive with pigs and non-human primates..
NCBI Gene ID
914
Swiss Prot
P06729
Host
Mouse
Reactivity
Human
Clonality
Monoclonal
Clone
RPA-2.10
Conjugation
Unconjugated
Type
Primary Antibodies, Functional Antibodies
Field of Research
Immunology
Purification
The monoclonal antibody was purified utilizing affinity chromatography. The endotoxin level is determined by LAL test to be less than 0.01 EU/µg of the protein.
Concentration
Batch dependent
Buffer
Phosphate-buffered aqueous solution, ph7.2.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
The product should be stored undiluted at 4˚ C . Do not freeze.
Product Datasheet
https://www.prosci-inc.com/?datasheet_sku=76-186
Fragment
Mouse IgG1, kappa
Specificity
The RPA-2.10 monoclonal antibody specifically binds to human CD2, a 50 kDA type I transmembrane glycoprotein.
Symbol
CD2
NCBI Official Name
CD2 molecule
NCBI Organism
Homo sapiens
Background Reference 01
Leucocyte typing IV: white cell differentiation antigens. Oxford University Press, 1989.
Background Reference 02
Hahn, W. C., Burakoff, S. J., Bierer, B. E. (1993) . Signal transduction pathways involved in T cell receptor-induced regulation of CD2 avidity for CD58.The Journal of Immunology,150 (7), 2607-2619.
Background Reference 03
Aversa, G. G., Bishop, G. A., Suranyi, M. G., Hall, B. M. (1987, February) . RPA-2.10: an anti-CD2 monoclonal antibody that inhibits alloimmune responses and monitors T cell activation. InTransplantation proceedings (Vol. 19, No. 1 Pt 1, pp. 277-278) .
Other Product Names
T11, SRBC, LFA-2, CD2
Tested Applications
Flow, Functional Assays
Physical Properties
Liquid
Curated Selection
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