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PRAK Antibody [7H10B4]

Product Specifications

Background

PRAK (p38-regulated /activated kinase), also referred to as mitogen-activated protein kinase (MAPK) -activated protein kinase (MAPKAPK) -5, is an ubiquitously expressed serine/threonine kinase regulated by p38α and p38β MAP kinases. Activated JNK, p38γ or p38δ are unable to induce phosphorylation of PRAK in vitro. Phosphorylation of PRAK occurs in vivo in response to p38 activation by stress-related extracellular stimuli including UV light, oxidation and proinflammatory cytokines. Two other substrates for p38, MAPKAPK-2 and MAPKAPK-3/3pK, share approximately 45% sequence homology with PRAK including the phosphorylation motif recognized by p38, Lys-X-Thr-Pro. Activated PRAK has been shown to specifically phosphorylate HSP 27 in vitro, suggesting that the protein may play a role in stress-induced small heat shock protein phosphorylation in vivo.

NCBI Gene ID

8550

Swiss Prot

Q8IW41

Accession Number

Q8IW41

Host

Mouse

Reactivity

Human

Immunogen

Ni-NTA purified truncated recombinant PRAK-His expressed in E. Coli strain BL21 (DE3) .

Clonality

Monoclonal

Clone

7H10B4

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Other

Concentration

Batch dependent

Buffer

Ascitic fluid containing 0.03% sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

PRAK monoclonal antibody can be stored at -20˚ C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Fragment

IgG1

Symbol

MAPKAPK5

NCBI Official Name

Mitogen-activated protein kinase-activated protein kinase 5

NCBI Organism

Homo sapiens

Background Reference 01

Paliga AJ. Natale DR. Watson AJ. Biol Cell. 2005, Aug, 97 (8) :629-40.

Background Reference 02

Wijtten PJ. Prak R. Lemme A. et al. Br Poult Sci. 2004, Aug, 45 (4) :504-11.

Background Reference 03

New L. Jiang Y. Han J. Mol Biol Cell. 2003, Jun, 14 (6) :2603-16. Epub 2003 Mar 20.

Other Product Names

PRAKMAPK-activated protein kinase 5, MK5, MK-5, PRAK, MAPKAP-K5

Tested Applications

ELISA, WB, IHC

Protein ID

52000829

Frequently Asked Questions

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