SMAD3-S208 Antibody

Product Specifications

Background

SMAD3 belongs to the SMAD, a family of proteins similar to the gene products of the Drosophila gene 'mothers against decapentaplegic' (Mad) and the C. elegans gene Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein functions as a transcriptional modulator activated by transforming growth factor-beta and is thought to play a role in the regulation of carcinogenesis.

NCBI Gene ID

4088

Swiss Prot

P84022

Accession Number

P84022

Host

Rabbit

Reactivity

Human, Mouse

Immunogen

This SMAD3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 186-215 amino acids from human SMAD3.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Cancer, Cell Cycle, Obesity, Neuroscience, Signal Transduction

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Homology

Predicted species reactivity based on immunogen sequence: Rat, Pig, Chicken

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

48 kDa

Fragment

Rabbit Ig

Symbol

SMAD3

NCBI Official Name

Mothers against decapentaplegic homolog 3

NCBI Organism

Homo sapiens

Background Reference 01

Zhang, M., et al. J. Biol. Chem. 285 (12) :8703-8710 (2010)

Background Reference 02

Daly, A.C., et al. J. Biol. Chem. 285 (9) :6489-6497 (2010)

Background Reference 03

Heikkinen, P.T., et al. J. Biol. Chem. 285 (6) :3740-3749 (2010)

Background Reference 04

Tseng, Z.H., et al. Heart Rhythm 6 (12) :1745-1750 (2009)

Other Product Names

Mothers against decapentaplegic homolog 3, MAD homolog 3, Mad3, Mothers against DPP homolog 3, hMAD-3, JV15-2, SMAD family member 3, SMAD 3, Smad3, hSMAD3, SMAD3, MADH3