ARC19499 (sodium)

ARC19499 sodium is an aptamer that inhibits tissue factor pathway inhibitor (TFPI), thereby enabling clot initiation and propagation via the extrinsic pathway. The core aptamer binds tightly and specifically to TFPI. ARC19499 sodium blocks TFPI inhibition of both factor Xa and the TF/factor VIIa complex. ARC19499 sodium corrects thrombin generation in hemophilia A and B plasma and restores clotting in FVIII-neutralized whole blood.

Product Specifications

Product Name Alternative

BAX499 (sodium)

UNSPSC

12352208

Target

Factor VIIa; Factor Xa; Tissue Factor Pathway Inhibitor (TFPI)

Type

Oligonucleotides

Related Pathways

Cytoskeleton; Metabolic Enzyme/Protease

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/arc19499-sodium.html

Purity

99.40

Solubility

10 mM in H2O

Smiles

[ARC19499(sodium)]

Molecular Weight

11837.60

References & Citations

[1]Waters EK, Genga RM, Schwartz MC, et al. Aptamer ARC19499 mediates a procoagulant hemostatic effect by inhibiting tissue factor pathway inhibitor. Blood. 2011;117 (20) :5514-5522.|[2]Gissel M, Orfeo T, Foley JH, Butenas S. Effect of BAX499 aptamer on tissue factor pathway inhibitor function and thrombin generation in models of hemophilia. Thromb Res. 2012;130 (6) :948-955.