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CAPN3 Antibody

Product Specifications

Background

Calpain, a heterodimer consisting of a large and a small subunit, is a major intracellular protease, although its function has not been well established. This gene encodes a muscle-specific member of the calpain large subunit family that specifically binds to titin. Mutations in this gene are associated with limb-girdle muscular dystrophies type 2A.

NCBI Gene ID

825

Swiss Prot

P20807

Accession Number

P20807

Host

Rabbit

Reactivity

Human

Immunogen

This CAPN3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 603-632 amino acids from the C-terminal region of human CAPN3.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Cell Cycle, Signal Transduction

Purification

This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis

Concentration

Batch dependent

Homology

Predicted species reactivity based on immunogen sequence: Monkey

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Product Datasheet

https://www.prosci-inc.com/?datasheet_sku=64-130

Calculated Molecular Weight

94 kDa

Fragment

Rabbit Ig

Symbol

CAPN3

NCBI Official Name

Calpain-3

NCBI Organism

Homo sapiens

Background Reference 01

Charlton, R., et al. Neuromuscul. Disord. 19 (7) :449-457 (2009)

Background Reference 02

Moretti, D., et al. Carcinogenesis 30 (6) :960-967 (2009)

Background Reference 03

Enjuanes, A., et al. Cancer Res. 68 (24) :10178-10186 (2008)

Background Reference 04

Beckmann, J.S., et al. Neuromuscul. Disord. 18 (12) :913-921 (2008)

Other Product Names

Calpain-3, Calcium-activated neutral proteinase 3, CANP 3, Calpain L3, Calpain p94, Muscle-specific calcium-activated neutral protease 3, New calpain 1, nCL-1, CAPN3, CANP3, CANPL3, NCL1

Tested Applications

WB, IHC-P, Flow

Physical Properties

Liquid

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