ZNF622 Antibody / ZPR9
Zinc-finger proteins contain DNA-binding domains and have a wide variety of functions, most of which encompass some form of transcriptional activation or repression. ZNF622 (zinc-finger protein 622), also known as ZPR9 (zinc-fingerlike protein 9), is a 477 amino acid protein that localizes to both the nucleus and the cytoplasm. Expressed in liver, spleen, lung, kidney and brain, ZNF622 is thought to activate the bound transcription factor B-Myb and, through this activation, may play a role in embryonic development. ZNF622 contains two U1-type zinc fingers and exists as either a homodimer or a heterodimer that can be phosphorylated by MELK (maternal embryonic leucine zipper kinase) . Overexpression of ZNF266 may be associated with liver metastases, carcinomatoses and colorectal carcinomas.
Product Specifications
CAS Number
9007-83-4
Specifications
Flow cytometry: 1-2ug/million cells, Immunofluorescence: 1-2 µg/mL
UniProt
Q969S3
Host
Mouse
Reactivity
Human
Immunogen
Recombinant full-length human ZNF622 protein was used as the immunogen for the ZNF622 antibody.
Clonality
Monoclonal
Isotype
IgG2a
Clone
PCRP-ZNF622-1C11
Applications
FACS, IF
Purity
Protein A/G affinity
Format
Purified
Buffer
0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide
Reconstitution
Aliquot the ZNF622 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Limitations
This ZNF622 antibody is available for research use only.
Storage Conditions
Aliquot the ZNF622 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Formulation
0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05% sodium azide
Applications Notes
Optimal dilution of the ZNF622 antibody should be determined by the researcher.
Location
Cytoplasm, Nucleus
Image Legend
Immunofluorescent staining of PFA-fixed human HeLa cells using ZNF622 antibody (green, clone PCRP-ZNF622-1C11) and phalloidin (red) .
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