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ACCN1 Antibody

Product Specifications

Background

ACCN1 encodes a member of the degenerin/epithelial sodium channel (DEG/ENaC) superfamily. The members of this family are amiloride-sensitive sodium channels that contain intracellular N and C termini, 2 hydrophobic transmembrane regions, and a large extracellular loop, which has many cysteine residues with conserved spacing. The member encoded by this protein may play a role in neurotransmission. In addition, a heteromeric association between this member and ACCN3 (variant 1) has been observed to co-assemble into proton-gated channels sensitive to gadolinium.

NCBI Gene ID

40

Swiss Prot

Q16515

Accession Number

Q16515

Host

Rabbit

Reactivity

Human

Immunogen

This ACCN1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 120-148 amino acids from the Central region of human ACCN1.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Neuroscience

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Homology

Predicted species reactivity based on immunogen sequence: Mouse, Rat

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

58 kDa

Fragment

Rabbit Ig

Symbol

ASIC2

NCBI Official Name

Acid-sensing ion channel 2

NCBI Organism

Homo sapiens

Background Reference 01

Bashari, E., et.al., Am. J. Physiol., Cell Physiol. 296 (2), C372-C384 (2009)

Background Reference 02

Chai, S., et.al., J. Biol. Chem. 282 (31), 22668-22677 (2007)

Other Product Names

Acid-sensing ion channel 2, ASIC2, Amiloride-sensitive brain sodium channel, Amiloride-sensitive cation channel 1, neuronal, Amiloride-sensitive cation channel neuronal 1, Brain sodium channel 1, BNC1, BNaC1, Mammalian degenerin homolog, ASIC2, ACCN, ACCN1, BNAC1, MDEG

Tested Applications

WB, IHC-P, Flow

Protein ID

2500840

Physical Properties

Liquid

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