DNA polymerase eta Antibody
Product Specifications
Background
This gene encodes a member of the Y family of specialized DNA polymerases. It copies undamaged DNA with a lower fidelity than other DNA-directed polymerases. However, it accurately replicates UV-damaged DNA; when thymine dimers are present, this polymerase inserts the complementary nucleotides in the newly synthesized DNA, thereby bypassing the lesion and suppressing the mutagenic effect of UV-induced DNA damage. This polymerase is thought to be involved in hypermutation during immunoglobulin class switch recombination. Mutations in this gene result in XPV, a variant type of xeroderma pigmentosum. Several transcript variants encoding different isoforms have been found for this gene.
NCBI Gene ID
5429
Swiss Prot
Q9Y253
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 20-320 of human DNA polymerase eta (NP_006493.1) .
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Other
Purification
Affinity purification
Positive Control
HeLa
Concentration
Batch dependent
Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at -20˚ C. Avoid freeze / thaw cycles.
Product Datasheet
https://www.prosci-inc.com/?datasheet_sku=18-337
Calculated Molecular Weight
Observed: 70kDa
Fragment
IgG
Symbol
POLH
Positive Control 2
HepG2
Positive Control 3
DU145
Positive Control 4
Raji
Positive Control 5
293T
NCBI Official Name
DNA polymerase eta
NCBI Organism
Homo sapiens
Other Product Names
RAD3RAD30A, XP-V, XPV, DNA polymerase eta, RAD30 homolog A, polymerase (DNA directed), eta, polymerase (DNA) eta, xeroderma pigmentosum variant type protein
Tested Applications
WB, IF
Physical Properties
Liquid
Curated Selection
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