PKD2 Antibody
Product Specifications
Background
Involved in fluid-flow mechanosensation by the primary cilium in renal epithelium. PKD1 and PKD2 may function through a common signaling pathway that is necessary for normal tubulogenesis. Acts as a regulator of cilium length, together with PKD1. The dynamic control of cilium length is essential in the regulation of mechanotransductive signaling. The cilium length response creates a negative feedback loop whereby fluid shear-mediated deflection of the primary cilium, which decreases intracellular cAMP, leads to cilium shortening and thus decreases flow-induced signaling. Functions as a calcium permeable cation channel.
NCBI Gene ID
5311
Swiss Prot
Q13563
Accession Number
Q13563
Host
Rabbit
Reactivity
Human
Immunogen
This PKD2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 937-968 amino acids from the C-terminal region of human PKD2.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Obesity, Signal Transduction
Purification
This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Product Datasheet
https://www.prosci-inc.com/?datasheet_sku=63-296
Calculated Molecular Weight
110 kDa
Fragment
Rabbit Ig
Symbol
PKD2
NCBI Official Name
Polycystin-2
NCBI Organism
Homo sapiens
Other Product Names
Polycystin-2, Autosomal dominant polycystic kidney disease type II protein, Polycystic kidney disease 2 protein, Polycystwin, R48321, PKD2
Tested Applications
WB, IHC-P
Protein ID
116242717
Physical Properties
Liquid
Curated Selection
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