IRS2 Antibody
Product Specifications
Background
Insulin receptor substrate 2, a cytoplasmic signaling molecule that mediates effects of insulin, insulin-like growth factor 1, and other cytokines by acting as a molecular adaptor between diverse receptor tyrosine kinases and downstream effectors. This protein is phosphorylated by the insulin receptor tyrosine kinase upon receptor stimulation, as well as by an interleukin 4 receptor-associated kinase in response to IL4 treatment.
NCBI Gene ID
8660
Swiss Prot
Q9Y4H2
Accession Number
Q9Y4H2
Host
Rabbit
Reactivity
Human
Immunogen
This IRS2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1309-1338 amino acids from the C-terminal region of human IRS2.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Obesity, Signal Transduction
Purification
This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
137 kDa
Fragment
Rabbit Ig
Symbol
IRS2
NCBI Official Name
Insulin receptor substrate 2
NCBI Organism
Homo sapiens
Background Reference 01
Hagg, D.A., Int. J. Mol. Med. 21 (6), 697-704 (2008)
Background Reference 02
Platanias, L.C., J. Biol. Chem. 271 (1), 278-282 (1996)
Background Reference 03
Sun, X.J., Nature 377 (6545), 173-177 (1995)
Other Product Names
Insulin receptor substrate 2, IRS-2, IRS2
Tested Applications
WB, IHC-P, IF
Protein ID
62298062
Physical Properties
Liquid
Frequently Asked Questions
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