PRAK Antibody

Product Specifications

Background

MAPKAPK5 is a member of the serine/threonine kinase family. In response to cellular stress and proinflammatory cytokines, this kinase is activated through its phosphorylation by MAP kinases including MAPK1/ERK, MAPK14/p38-alpha, and MAPK11/p38-beta. In vitro, this kinase phosphorylates heat shock protein HSP27 at its physiologically relevant sites.

NCBI Gene ID

8550

Swiss Prot

Q8IW41

Accession Number

Q8IW41

Host

Rabbit

Reactivity

Human

Immunogen

This PRAK (MAPKAPK5) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 160-189 amino acids from human PRAK (MAPKAPK5) .

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Cancer

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

54 kDa

Fragment

Rabbit Ig

Applications Notes

For WB starting dilution is: 1:1000

Symbol

MAPKAPK5

NCBI Official Name

MAP kinase-activated protein kinase 5

NCBI Organism

Homo sapiens

Background Reference 01

New, L., et al., EMBO J. 17 (12) :3372-3384 (1998) .

Background Reference 02

Ni, H., et al., Biochem. Biophys. Res. Commun. 243 (2) :492-496 (1998) .

Background Reference 03

Sudo T., Biochem. Biophys. Res. Commun. 269:521-525 (2000) .

Other Product Names

MAP kinase-activated protein kinase 5, MAPK-activated protein kinase 5, MAPKAP kinase 5, MAPKAP-K5, MAPKAPK-5, MK-5, MK5, p38-regulated/activated protein kinase, PRAK, MAPKAPK5, PRAK