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SSB Antibody

Product Specifications

Background

SSB is involved in diverse aspects of RNA metabolism, including binding and protecting 3-prime UUU (OH) elements of newly RNA polymerase III -transcribed RNA, processing 5-prime and 3-prime ends of pre-tRNA precursors, acting as an RNA chaperone, and binding viral RNAs associated with hepatitis C virus. This protein was originally defined by its reactivity with autoantibodies from patients with Sjogren syndrome and systemic lupus erythematosus.

NCBI Gene ID

6741

Swiss Prot

P05455

Accession Number

P05455

Host

Rabbit

Reactivity

Human

Immunogen

This SSB antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 366-397 amino acids from the C-terminal region of human SSB.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Immunology

Purification

This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis

Concentration

Batch dependent

Homology

Predicted species reactivity based on immunogen sequence: Rb

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

47 kDa

Fragment

Rabbit Ig

Symbol

SSB

NCBI Official Name

Lupus La protein

NCBI Organism

Homo sapiens

Background Reference 01

Bitko, V., J. Virol. 82 (16), 7977-7987 (2008)

Background Reference 02

Kotik-Kogan, O., Structure 16 (6), 852-862 (2008)

Background Reference 03

Biswas, D., Clin. Rheumatol. 27 (6), 717-722 (2008)

Other Product Names

Lupus La protein, La autoantigen, La ribonucleoprotein, Sjoegren syndrome type B antigen, SS-B, SSB

Tested Applications

WB, IHC-P

Protein ID

125985

Physical Properties

Liquid

Frequently Asked Questions

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