What is the catalog number for Cellular Apoptosis Susceptibility Antibody?

The catalog number for Cellular Apoptosis Susceptibility Antibody is 60-497.

What sizes are available for Cellular Apoptosis Susceptibility Antibody?

Cellular Apoptosis Susceptibility Antibody is available in the following size(s): 400 µL.

Is Cellular Apoptosis Susceptibility Antibody in stock?

Cellular Apoptosis Susceptibility Antibody is currently made to order / not held in immediate stock. Contact us for lead time.

Cellular Apoptosis Susceptibility Antibody

Product Specifications

Background

Proteins that carry a nuclear localization signal (NLS) are transported into the nucleus by the importin-alpha/beta heterodimer. Importin-alpha binds the NLS, while importin-beta mediates translocation through the nuclear pore complex. After translocation, RanGTP binds importin-beta and displaces importin-alpha. Importin-alpha must then be returned to the cytoplasm, leaving the NLS protein behind. CSE1L binds strongly to NLS-free importin-alpha, and this binding is released in the cytoplasm by the combined action of RANBP1 and RANGAP1. In addition, CSE1L may play a role both in apoptosis and in cell proliferation.

NCBI Gene ID

1434

Swiss Prot

P55060

Accession Number

P55060

Host

Rabbit

Reactivity

Human, Mouse

Immunogen

This Cellular Apoptosis Susceptibility antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 55-84 amino acids from the N-terminal region of human Cellular Apoptosis Susceptibility.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Cell Cycle, Signal Transduction

Purification

This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis

Concentration

Batch dependent

Homology

Predicted species reactivity based on immunogen sequence: Zebrafish, Bovine

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

110 kDa

Fragment

Rabbit Ig

Symbol

CSE1L

NCBI Official Name

Exportin-2

NCBI Organism

Homo sapiens

Background Reference 01

Goldberg, G.S., et al., J. Biol. Chem. 278 (47) :46533-46540 (2003) .

Background Reference 02

Behrens, P., et al., Apoptosis 8 (1) :39-44 (2003) .

Background Reference 03

Jiang, M.C., et al., Biochem. Biophys. Res. Commun. 294 (4) :900-905 (2002) .

Background Reference 04

Wellmann, A., et al., Int. J. Mol. Med. 7 (5) :489-494 (2001) .

Other Product Names

Exportin-2, Exp2, Cellular apoptosis susceptibility protein, Chromosome segregation 1-like protein, Importin-alpha re-exporter, CSE1L, CAS, XPO2

Tested Applications

WB, IHC-P, IF

Protein ID

62297557

Physical Properties

Liquid

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