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Mouse Cbx5 Antibody

Product Specifications

Background

Component of heterochromatin that recognizes and binds histone H3 tails methylated at 'Lys-9' (H3K9me), leading to epigenetic repression. In contrast, it is excluded from chromatin when 'Tyr-41' of histone H3 is phosphorylated (H3Y41ph) . Can interact with lamin-B receptor (LBR) . This interaction can contribute to the association of the heterochromatin with the inner nuclear membrane. Involved in the formation of functional kinetochore through interaction with MIS12 complex proteins (By similarity) .

NCBI Gene ID

12419

Swiss Prot

Q61686

Accession Number

Q61686

Host

Rabbit

Reactivity

Mouse

Immunogen

This Mouse Cbx5 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 160-186 amino acids from the C-terminal region of mouse Cbx5.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Other

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Homology

Predicted species reactivity based on immunogen sequence: Human

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Product Datasheet

https://www.prosci-inc.com/?datasheet_sku=60-399

Calculated Molecular Weight

22 kDa

Fragment

Rabbit Ig

Applications Notes

For WB starting dilution is: 1:1000

Symbol

Cbx5

NCBI Official Name

Chromobox protein homolog 5

NCBI Organism

Mus musculus

Background Reference 01

Sun, Y., et al. Biophys. J. 99 (4) :1274-1283 (2010)

Background Reference 02

Muller, K.P., et al. Biophys. J. 97 (11) :2876-2885 (2009)

Background Reference 03

Dong, K.B., et al. EMBO J. 27 (20) :2691-2701 (2008)

Background Reference 04

Villeneuve, L.M., et al. Proc. Natl. Acad. Sci. U.S.A. 105 (26) :9047-9052 (2008)

Other Product Names

Chromobox protein homolog 5, Heterochromatin protein 1 homolog alpha, HP1 alpha, Cbx5, Hp1a

Tested Applications

WB

Physical Properties

Liquid

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