CLSTN1 Antibody

Product Specifications

Background

Induces KLC1 association with vesicles and functions as a cargo in axonal anterograde transport. Complex formation with APBA2 and APP, stabilizes APP metabolism and enhances APBA2-mediated suppression of beta-APP40 secretion, due to the retardation of intracellular APP maturation. In complex with APBA2 and C99, a C-terminal APP fragment, abolishes C99 interaction with PSEN1 and thus APP C99 cleavage by gamma-secretase, most probably through stabilization of the direct interaction between APBA2 and APP. The intracellular fragment AlcICD suppresses APBB1-dependent transactivation stimulated by APP C-terminal intracellular fragment (AICD), most probably by competing with AICD for APBB1-binding. May modulate calcium-mediated postsynaptic signals (By similarity) .

NCBI Gene ID

22883

Swiss Prot

O94985

Accession Number

O94985

Host

Rabbit

Reactivity

Human

Immunogen

This CLSTN1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 15-42 amino acids from the N-terminal region of human CLSTN1.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Neuroscience

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Homology

Predicted species reactivity based on immunogen sequence: Mouse, Rat

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

110 kDa

Fragment

Rabbit Ig

Applications Notes

For WB starting dilution is: 1:1000

Symbol

CLSTN1

NCBI Official Name

Calsyntenin-1

NCBI Organism

Homo sapiens

Background Reference 01

Konecna, A., et al. Mol. Biol. Cell 17 (8) :3651-3663 (2006)

Background Reference 02

Wang, A.G., et al. Biochem. Biophys. Res. Commun. 345 (3) :1022-1032 (2006)

Background Reference 03

Araki, Y., et al. J. Biol. Chem. 279 (23) :24343-24354 (2004)

Background Reference 04

Schmitt-Ulms, G., et al. Nat. Biotechnol. 22 (6) :724-731 (2004)

Other Product Names

Calsyntenin-1, Alcadein-alpha, Alc-alpha, Alzheimer-related cadherin-like protein, Non-classical cadherin XB31alpha, Soluble Alc-alpha, SAlc-alpha, CTF1-alpha, C-terminal fragment 1-alpha, CLSTN1, CS1, KIAA0911