MKL1 Antibody

Product Specifications

Background

The protein encoded by this gene interacts with the transcription factor myocardin, a key regulator of smooth muscle cell differentiation. The encoded protein is predominantly nuclear and may help transduce signals from the cytoskeleton to the nucleus. This gene is involved in a specific translocation event that creates a fusion of this gene and the RNA-binding motif protein-15 gene. This translocation has been associated with acute megakaryocytic leukemia.

NCBI Gene ID

57591

Swiss Prot

Q969V6

Accession Number

Q969V6

Host

Rabbit

Reactivity

Human

Immunogen

This MKL1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 497-525 amino acids from the Central region of human MKL1.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Obesity, Signal Transduction

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

99 kDa

Fragment

Rabbit Ig

Applications Notes

For WB starting dilution is: 1:1000

Symbol

MKL1

NCBI Official Name

MKL/myocardin-like protein 1

NCBI Organism

Homo sapiens

Background Reference 01

Gilles, L., et al. Blood 114 (19) :4221-4232 (2009)

Background Reference 02

Hinohara, K., et al. Hum. Genet. 126 (4) :539-547 (2009)

Background Reference 03

Estrada, K., et al. Hum. Mol. Genet. 18 (18) :3516-3524 (2009)

Background Reference 04

Brandt, D.T., et al. Nat. Cell Biol. 11 (5) :557-568 (2009)

Other Product Names

MKL/myocardin-like protein 1, Megakaryoblastic leukemia 1 protein, Megakaryocytic acute leukemia protein, Myocardin-related transcription factor A, MRTF-A, MKL1, KIAA1438, MAL