Recombinant Phospho-PERK (Thr980) Monoclonal Antibody
Product Specifications
Background
The protein encoded by this gene phosphorylates the alpha subunit of eukaryotic translation-initiation factor 2, leading to its inactivation, and thus to a rapid reduction of translational initiation and repression of global protein synthesis. This protein is thought to modulate mitochondrial function. It is a type I membrane protein located in the endoplasmic reticulum (ER), where it is induced by ER stress caused by malfolded proteins. Mutations in this gene are associated with Wolcott-Rallison syndrome.
Abbreviation
PERK
UniProt
Q9Z2B5
Host
Rabbit
Reactivity
Mouse; Rat
Immunogen
A synthetic peptide corresponding to residues around (Thr980) of Mouse Phospho-PERK
Target
EIF2AK; Pek; Perk; Eif2ak3
Clonality
Monoclonal,Recombinant
Clone
10A11
Conjugation
Unconjugated
Applications
WB
Purification
Protein A
Concentration
0.2 mg/mL
Dilution
WB 1:2000-1:10000
Buffer
PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.
Shipping Conditions
Ice bag
Storage Conditions
Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
Calculated Molecular Weight
125 kDa
Observed Molecular Weight
125 kDa
Isotype
IgG, κ
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