GPNMB Antibody

Product Specifications

Background

The protein encoded by this gene is a type I transmembrane glycoprotein which shows homology to the pMEL17 precursor, a melanocyte-specific protein. GPNMB shows expression in the lowly metastatic human melanoma cell lines and xenografts but does not show expression in the highly metastatic cell lines. GPNMB may be involved in growth delay and reduction of metastatic potential. Two transcript variants encoding different isoforms have been found for this gene.

NCBI Gene ID

10457

Swiss Prot

Q14956

Accession Number

Q14956

Host

Rabbit

Reactivity

Human

Immunogen

This GPNMB antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 541-569 amino acids from the C-terminal region of human GPNMB.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Cancer, Immunology

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

64 kDa

Fragment

Rabbit Ig

Applications Notes

For WB starting dilution is: 1:500

Symbol

GPNMB

NCBI Official Name

Transmembrane glycoprotein NMB

NCBI Organism

Homo sapiens

Background Reference 01

Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :

Background Reference 02

Williams, M.D., et al. Melanoma Res. 20 (3) :184-190 (2010)

Background Reference 03

Hoashi, T., et al. FASEB J. 24 (5) :1616-1629 (2010)

Background Reference 04

Rose, A.A., et al. Clin. Cancer Res. 16 (7) :2147-2156 (2010)

Other Product Names

Transmembrane glycoprotein NMB, Transmembrane glycoprotein HGFIN, GPNMB, HGFIN, NMB

Tested Applications

Protein ID

61252504

Physical Properties

Liquid

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