Ro18-5362

Ro18-5362 is the less active proagent of Ro 18-5364. Even at concentrations as high as 0.1 mM Ro 18-5362 fails to affect significantly (H++K+) -ATPase activity and associated proton translocation.

Product Specifications

CAS Number

[101387-97-7]

UNSPSC

12352005

Target

Na+/K+ ATPase

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/Ro18-5362.html

Solubility

10 mM in DMSO

Smiles

O=C1C(C)(C)C2=C(C=C3NC(SCC4=NC=CC(OC)=C4C)=NC3=C2)C1(C)C

Molecular Formula

C22H25N3O2S

Molecular Weight

395.52

References & Citations

[1]Sigrist-Nelson K, et al. Ro 18-5364, a potent new inhibitor of the gastric (H+ + K+) -ATPase. Eur J Biochem. 1987 Jul 15;166 (2) :453-9.|[2]Sigrist-Nelson K, et al. Gastric (H+ + K+) -ATPase: modulation of the inhibitory properties of the novel potent antisecretagogue Ro 18-5364 by sulfhydryl reagents and nucleotides. FEBS Lett. 1986 Mar 3;197 (1-2) :187-91.