USP1 Antibody

Product Specifications

Background

This gene encodes a member of the ubiquitin-specific processing (UBP) family of proteases that is a deubiquitinating enzyme (DUB) with His and Cys domains. This protein is located in the cytoplasm and cleaves the ubiquitin moiety from ubiquitin-fused precursors and ubiquitinylated proteins. The protein specifically deubiquitinates a protein in the Fanconi anemia (FA) DNA repair pathway. Alternate transcriptional splice variants have been characterized.

NCBI Gene ID

7398

Swiss Prot

O94782

Accession Number

O94782

Host

Rabbit

Reactivity

Human

Immunogen

This USP1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 662-690 amino acids from the C-terminal region of human USP1.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Cell Cycle

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Homology

Predicted species reactivity based on immunogen sequence: Bovine, Mouse

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

88 kDa

Fragment

Rabbit Ig

Applications Notes

For WB starting dilution is: 1:1000

Symbol

USP1

NCBI Official Name

Ubiquitin carboxyl-terminal hydrolase 1

NCBI Organism

Homo sapiens

Background Reference 01

Barroso, E., et al. Breast Cancer Res. Treat. 118 (3) :655-660 (2009)

Background Reference 02

McWilliams, R.R., et al. Cancer Epidemiol. Biomarkers Prev. 18 (9) :2549-2552 (2009)

Background Reference 03

Cohn, M.A., et al. J. Biol. Chem. 284 (8) :5343-5351 (2009)

Background Reference 04

Cohn, M.A., et al. Mol. Cell 28 (5) :786-797 (2007)

Other Product Names

Ubiquitin carboxyl-terminal hydrolase 1, Deubiquitinating enzyme 1, hUBP, Ubiquitin thioesterase 1, Ubiquitin-specific-processing protease 1, USP1

Tested Applications

Physical Properties

Liquid

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