ELAVL3 Antibody

Product Specifications

Background

A member of the ELAVL protein family, ELAV-like 3 is a neural-specific RNA-binding protein which contains three RNP-type RNA recognition motifs. The observation that ELAVL3 is one of several Hu antigens (neuronal-specific RNA-binding proteins) recognized by the anti-Hu serum antibody present in sera from patients with paraneoplastic encephalomyelitis and sensory neuronopathy (PEM/PSN) suggests it has a role in neurogenesis. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.

NCBI Gene ID

1995

Swiss Prot

Q14576

Accession Number

Q14576

Host

Rabbit

Reactivity

Human

Immunogen

This ELAVL3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 71-99 amino acids from the N-terminal region of human ELAVL3.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Neuroscience

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Homology

Predicted species reactivity based on immunogen sequence: Mouse

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

40 kDa

Fragment

Rabbit Ig

Symbol

ELAVL3

NCBI Official Name

ELAV-like protein 3

NCBI Organism

Homo sapiens

Background Reference 01

Behrends, U., et al. Int. J. Cancer 100 (6) :669-677 (2002)

Background Reference 02

Park, S., et al. Mol. Cell. Biol. 20 (13) :4765-4772 (2000)

Background Reference 03

King, P.H. Nucleic Acids Res. 28 (7), E20 (2000) :

Background Reference 04

Sakai, K., et al. Biochem. Biophys. Res. Commun. 256 (2) :263-268 (1999)

Other Product Names

ELAV-like protein 3, Hu-antigen C, HuC, Paraneoplastic cerebellar degeneration-associated antigen, Paraneoplastic limbic encephalitis antigen 21, ELAVL3, HUC, PLE21