PIGA Antibody

Product Specifications

Background

This gene encodes a protein required for synthesis of N-acetylglucosaminyl phosphatidylinositol (GlcNAc-PI), the first intermediate in the biosynthetic pathway of GPI anchor. The GPI anchor is a glycolipid found on many blood cells and which serves to anchor proteins to the cell surface. Paroxysmal nocturnal hemoglobinuria, an acquired hematologic disorder, has been shown to result from mutations in this gene. Alternate splice variants have been characterized. A related pseudogene is located on chromosome 12.

NCBI Gene ID

5277

Swiss Prot

P37287

Accession Number

P37287

Host

Rabbit

Reactivity

Human

Immunogen

This PIGA antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 455-484 amino acids from the C-terminal region of human PIGA.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Other

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

54 kDa

Fragment

Rabbit Ig

Symbol

PIGA

NCBI Official Name

Phosphatidylinositol N-acetylglucosaminyltransferase subunit A

NCBI Organism

Homo sapiens

Background Reference 01

Borowitz, M.J., et al. CytometryClin Cytom 78 (4) :211-230 (2010)

Background Reference 02

Peruzzi, B., et al. Mutat. Res. 705 (1) :3-10 (2010)

Background Reference 03

Araten, D.J., et al. Mutat. Res. 686 (1-2), 1-8 (2010) :

Background Reference 04

Iida, Y., et al. Blood 83 (11) :3126-3131 (1994)

Other Product Names

Phosphatidylinositol N-acetylglucosaminyltransferase subunit A, GlcNAc-PI synthesis protein, Phosphatidylinositol-glycan biosynthesis class A protein, PIG-A, PIGA