Succinyl- (Pro58, D-Glu65) -Hirudin (56-65) (sulfated)
Succinyl- (Pro58, D-Glu65) -Hirudin (56-65) (sulfated) is a hirugen-like peptide, and has high affnity for thrombin than Hirugen, with a KD 50 value of 0.087 μM[1].
Product Specifications
CAS Number
131791-98-5
UNSPSC
12352209
Target
Thrombin
Type
Peptides
Related Pathways
Metabolic Enzyme/Protease
Applications
Neuroscience-Neuromodulation
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/succinyl-pro58-d-glu65-hirudin-56-65-sulfated.html
Solubility
10 mM in DMSO
Smiles
O=C([C@H]1N(CCC1)C([C@H](CCC(O)=O)NC([C@@H](NC(CCC(O)=O)=O)CC2=CC=CC=C2)=O)=O)N[C@@H]([C@@H](C)CC)C(N3[C@@H](CCC3)C(N[C@@H](CCC(O)=O)C(N[C@@H](CCC(O)=O)C(N[C@H](C(N[C@@H](CC(C)C)C(N[C@@H](C(O)=O)CCC(O)=O)=O)=O)CC4=CC=C(C=C4)OS(=O)(O)=O)=O)=O)=O)=O
Molecular Formula
C64H88N10O26S
Molecular Weight
1445.50
References & Citations
[1]Dekker RJ, et al. The variable region-1 from tissue-type plasminogen activator confers specificity for plasminogen activator inhibitor-1 to thrombin by facilitating catalysis: release of a kinetic block by a heterologous protein surface loop. J Mol Biol. 1999 Oct 29;293 (3) :613-27.|[2]Payne MH, et al. Positional effects of sulfation in hirudin and hirudin PA related anticoagulant peptides. J Med Chem. 1991 Mar;34 (3) :1184-7.
Shipping Conditions
Room temperature
Scientific Category
Peptides
Clinical Information
No Development Reported
Frequently Asked Questions
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