AKR1C2 Antibody

Product Specifications

Background

This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. These enzymes catalyze the conversion of aldehydes and ketones to their corresponding alcohols using NADH and/or NADPH as cofactors. The enzymes display overlapping but distinct substrate specificity. This enzyme binds bile acid with high affinity, and shows minimal 3-alpha-hydroxysteroid dehydrogenase activity. This gene shares high sequence identity with three other gene members and is clustered with those three genes at chromosome 10p15-p14.

NCBI Gene ID

1646

Swiss Prot

P52895

Accession Number

P52895

Host

Rabbit

Reactivity

Human

Immunogen

This AKR1C2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 296-323 amino acids from the C-terminal region of human AKR1C2.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Cancer, Cell Cycle, Obesity, Signal Transduction

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration

Batch dependent

Homology

Predicted species reactivity based on immunogen sequence: Monkey

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Calculated Molecular Weight

37 kDa

Fragment

Rabbit Ig

Symbol

AKR1C2

NCBI Official Name

Aldo-keto reductase family 1 member C2

NCBI Organism

Homo sapiens

Background Reference 01

Setlur, S.R., et al. Cancer Epidemiol. Biomarkers Prev. 19 (1) :229-239 (2010)

Background Reference 02

Wang, X., et al. PLoS ONE (8), E11934 (2010) :

Background Reference 03

Reding, K.W., et al. Am. J. Epidemiol. 170 (10) :1241-1249 (2009)

Background Reference 04

Cogliati, C., et al. FEBS J. 276 (20) :6011-6023 (2009)

Other Product Names

Aldo-keto reductase family 1 member C2, 1---, 3-alpha-HSD3, Chlordecone reductase homolog HAKRD, Dihydrodiol dehydrogenase 2, DD-2, DD2, Dihydrodiol dehydrogenase/bile acid-binding protein, DD/BABP, Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase, Type III 3-alpha-hydroxysteroid dehydrogenase, AKR1C2, DDH2