TRIM72 Antibody
Product Specifications
Background
TRIM72 is a muscle-specific protein that plays a central role in cell membrane repair by nucleating the assembly of the repair machinery at injury sites. Specifically binds phosphatidylserine. Acts as a sensor of oxidation: upon membrane damage, entry of extracellular oxidative environment results in disulfide bond formation and homooligomerization at the injury site. This oligomerization acts as a nucleation site for recruitment of TRIM72-containing vesicles to the injury site, leading to membrane patch formation. Probably acts upstream of the Ca (2+) -dependent membrane resealing process. Required for transport of DYSF to sites of cell injury during repair patch formation. Regulates membrane budding and exocytosis. May be involved in the regulation of the mobility of KCNB1-containing endocytic vesicles (By similarity) .
NCBI Gene ID
493829
Swiss Prot
Q6ZMU5
Accession Number
Q6ZMU5
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
This TRIM72 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 299-327 amino acids from the C-terminal region of human TRIM72.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cell Cycle, Signal Transduction
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
53 kDa
Fragment
Rabbit Ig
Symbol
TRIM72
NCBI Official Name
Tripartite motif-containing protein 72
NCBI Organism
Homo sapiens
Background Reference 01
Park, E.Y., et al. Proteins 78 (3) :790-795 (2010)
Background Reference 02
Han, S., et al. Hum. Mol. Genet. 18 (6) :1171-1180 (2009)
Background Reference 03
Martin, J., et al. Nature 432 (7020) :988-994 (2004)
Other Product Names
HGNC:32671
Tested Applications
WB, IHC-P
Protein ID
126253816
Physical Properties
Liquid
Curated Selection
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