KSR2 Antibody
Product Specifications
Background
Location-regulated scaffold connecting MEK to RAF. Blocks MAP3K8 kinase activity and MAP3K8-mediated signaling. Acts as a negative regulator of MAP3K3-mediated activation of ERK, JNK and NF-kappa-B pathways, inhibiting MAP3K3-mediated interleukin-8 production.
NCBI Gene ID
283455
Swiss Prot
Q6VAB6
Accession Number
Q6VAB6
Host
Rabbit
Reactivity
Human
Immunogen
This KSR2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 603-638 amino acids from the C-terminal region of human KSR2.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Signal Transduction
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Product Datasheet
https://www.prosci-inc.com/?datasheet_sku=55-850
Calculated Molecular Weight
108 kDa
Fragment
Rabbit Ig
Symbol
KSR2
NCBI Official Name
Kinase suppressor of Ras 2
NCBI Organism
Homo sapiens
Background Reference 01
Bailey, S.D., et al. Diabetes Care (2010) In press :
Background Reference 02
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Background Reference 03
Talmud, P.J., et al. Am. J. Hum. Genet. 85 (5) :628-642 (2009)
Background Reference 04
Liu, L., et al. Biochim. Biophys. Acta 1794 (10) :1485-1495 (2009)
Other Product Names
Kinase suppressor of Ras 2, hKSR2, KSR2
Tested Applications
WB, IHC-P, Flow
Protein ID
148886599
Physical Properties
Liquid
Curated Selection
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