NS3 Antibody [1B6]
Product Specifications
Background
The NS3 serine protease, in association with NS4A, is responsible for the cleavages of the Hepatitis C virus protease complexes NS3-NS4A, NS4A-NS4B, NS4B-NS5A and NS5A-NS5B. NS5B is a RNA-dependent RNA polymerase that plays an essential role in the virus replication. Hepatitis C virus protease NS3-NS4A colocalizes with IPS-1/VISA/MAVS/Cardif in the mitochondrial membrane and has been shown to cleave the TLR3 adapter TRIF and Cardif to eliminate the antiviral signaling pathways. NS3-NS4A represents an important target for anti-HCV drugs.
Host
Mouse
Reactivity
HCV
Immunogen
Recombinant hepatitis C virus (HCV) NS3 serine protease domain.
Clonality
Monoclonal
Clone
1B6
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Innate Immunity
Purification
>95% (SDS-PAGE)
Concentration
1 mg/ml
Buffer
Liquid. In PBS containing 10% glycerol and 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Stable for at least 1 year after receipt when stored at -20˚ C.
Fragment
IgG1
Specificity
Recognizes HCV NS3 (genotype 1a and 1b) (epitope mapped to NS3 aa 160-193), recognizes NS3 alone or the NS3-4A complex. Does not cross-react with HCV NS3 (genotype 2a) . t
Applications Notes
Immunocytochemistry: (paraformaldehyde fixation) (1:50) . Western Blot: (1:500) .
Other Product Names
Nonstructural Protein 3
Tested Applications
ICC, WB
Physical Properties
Liquid
Frequently Asked Questions
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