Anti-GPRC5D-Anti-CD3 Bispecific Antibody

The  orphan G protein–coupled receptor, class C group 5 member D (GPRC5D) is a retinoic acid-inducible protein with seven transmembrane segments and a short N-terminal extracellular region. The strong and selective expression of GPRC5D in Multiple Myeloma (MM) cells, similar to the expression pattern of B-cell maturation antigen (BCMA), makes it a promising target for the treatment of MM. It is anticipated that GPRC5D will be an alternative CAR (chimeric antigen receptor) -T cell target for MM immunotherapy.

Anti-GPRC5D-Anti-CD3 Bispecific Antibody can be used for studying GPRC5D+ cancer cell-mediated T cell activation, using either primary T cells or reporter cell lines such NFAT Luciferase Reporter Jurkat Cell Line (#60621) .